El-Tawil,, M., Abdel-Lateef, M., Abou-Donia, S. (2008). THE ACUTE ORAL TOXICITY OF CHLORPYRIFOS AND CYPERMETHRIN AND THEIR MIXTURE ON ALBINO RATS. Journal of Plant Protection and Pathology, 33(1), 509-518. doi: 10.21608/jppp.2008.217650
M. F.M.A. El-Tawil,; M. F. Abdel-Lateef; S. A. Abou-Donia. "THE ACUTE ORAL TOXICITY OF CHLORPYRIFOS AND CYPERMETHRIN AND THEIR MIXTURE ON ALBINO RATS". Journal of Plant Protection and Pathology, 33, 1, 2008, 509-518. doi: 10.21608/jppp.2008.217650
El-Tawil,, M., Abdel-Lateef, M., Abou-Donia, S. (2008). 'THE ACUTE ORAL TOXICITY OF CHLORPYRIFOS AND CYPERMETHRIN AND THEIR MIXTURE ON ALBINO RATS', Journal of Plant Protection and Pathology, 33(1), pp. 509-518. doi: 10.21608/jppp.2008.217650
El-Tawil,, M., Abdel-Lateef, M., Abou-Donia, S. THE ACUTE ORAL TOXICITY OF CHLORPYRIFOS AND CYPERMETHRIN AND THEIR MIXTURE ON ALBINO RATS. Journal of Plant Protection and Pathology, 2008; 33(1): 509-518. doi: 10.21608/jppp.2008.217650
THE ACUTE ORAL TOXICITY OF CHLORPYRIFOS AND CYPERMETHRIN AND THEIR MIXTURE ON ALBINO RATS
Department of Plant Protection, Faculty of Agriculture, Al-Azhar University, Nasr City, Cairo, Egypt
Abstract
The overall purpose of this work is to throw some light on the acute oral toxic effects of three commercial formulations of chlorpyrifos (i.e. Dursban, Pyriban and Chlorzan) 48% E.C. and cypermethrin (Sparkil 25% E.C.) and the mixture of Dursban and Sparkil on adult male and female albino rats. All the tested formulations were administered in corn oil to the rats and the median lethal doses (LD50 values) were determined after 24, 48, 72 and 96 hours (hrs) of treatment.
The obtained results revealed that the oral LD50 values of the tested insecticide formulations (Dursban, Pyriban, Chlorzan and Sparkil) on adult male and female rats were (125, 115), (100, 94), (140, 103) and (387, 251) mg/Kg body weight (b.w.) after 24 hrs, respectively. The 48hrs oral LD50 values of the fore mentioned formulations were (112, 90), (100, 75), (126, 81) and (230, 206) mg/Kg b.w., respectively.
On the other hand, the acute oral toxicity of the mixture of Dursban and Sparkil was considerably higher than the acute toxicity of each of them since the acute oral LD50 values were 102 and 75 mg/Kg b.w. for male and female rats after 24hrs, respectively.
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