EFFECT OF DELTAMETHRIN ON DRUG METABOLIZING ENZYMES IN MALE MICE LIVER

The present study was undertaken to investigate the effects of a single (24 h)
and repeated (7 days) doses of deltamethrin (10 rngikg body weight daily) on
hepatic drug metabolizing enzymes. The hepatic content of microsomal protein,
cytochrome P450 and b5. activities of NADPH cytochrome C reductase, amidopyrine
N—demethylase. aniline-4shydroxylase. glutathion S-transeferase and the level of
thiobarbituric acid reactive substances (TEARS) were determined. The obtained
results indicated that a single dose of deltamethrin had no significant effect on
hepatic microsomal proteins, cytochrome b5, amidopyn‘ne N-demethylase, aniline-4-
hydroxylase, or TEARS. However, it significantly decreased (p < 0.05) the activity of
cytochrome P450. and increased the activities of NADPH cytochrome C reductase
{p < 0.001) and glutathion S-transeferase (pit-0.05). Repeated doses of deltamethrin
significantly decreased the activities of hepatic microsomal proteins (ps0.05) and
amidopyrine N-demethylase (p¢0.001), and increased the activities (Ps0.01) of other
studied enzymes. The obtained results indicated that single and repeated doses of
deltamethrin had marked effects on hepatic drug metabolizing enzymes.