El-Banna., S. (2006). EFFECT OF DELTAMETHRIN ON DRUG METABOLIZING ENZYMES IN MALE MICE LIVER. Journal of Plant Protection and Pathology, 31(5), 3247-3255. doi: 10.21608/jppp.2006.235224
Sabah G. El-Banna.. "EFFECT OF DELTAMETHRIN ON DRUG METABOLIZING ENZYMES IN MALE MICE LIVER". Journal of Plant Protection and Pathology, 31, 5, 2006, 3247-3255. doi: 10.21608/jppp.2006.235224
El-Banna., S. (2006). 'EFFECT OF DELTAMETHRIN ON DRUG METABOLIZING ENZYMES IN MALE MICE LIVER', Journal of Plant Protection and Pathology, 31(5), pp. 3247-3255. doi: 10.21608/jppp.2006.235224
El-Banna., S. EFFECT OF DELTAMETHRIN ON DRUG METABOLIZING ENZYMES IN MALE MICE LIVER. Journal of Plant Protection and Pathology, 2006; 31(5): 3247-3255. doi: 10.21608/jppp.2006.235224
EFFECT OF DELTAMETHRIN ON DRUG METABOLIZING ENZYMES IN MALE MICE LIVER
Department of Environmental Studies. Institute of Graduate Studies and Research. Alexandria University, 163 Horreya Avenue. P.O. Box 832, Alexandria 21526. Egypt.
Abstract
The present study was undertaken to investigate the effects of a single (24 h)
and repeated (7 days) doses of deltamethrin (10 rngikg body weight daily) on
hepatic drug metabolizing enzymes. The hepatic content of microsomal protein,
cytochrome P450 and b5. activities of NADPH cytochrome C reductase, amidopyrine
N—demethylase. aniline-4shydroxylase. glutathion S-transeferase and the level of
thiobarbituric acid reactive substances (TEARS) were determined. The obtained
results indicated that a single dose of deltamethrin had no significant effect on
hepatic microsomal proteins, cytochrome b5, amidopyn‘ne N-demethylase, aniline-4-
hydroxylase, or TEARS. However, it significantly decreased (p < 0.05) the activity of
cytochrome P450. and increased the activities of NADPH cytochrome C reductase
{p < 0.001) and glutathion S-transeferase (pit-0.05). Repeated doses of deltamethrin
significantly decreased the activities of hepatic microsomal proteins (ps0.05) and
amidopyrine N-demethylase (p¢0.001), and increased the activities (Ps0.01) of other
studied enzymes. The obtained results indicated that single and repeated doses of
deltamethrin had marked effects on hepatic drug metabolizing enzymes.
Top