EI-Kady,, A., Farrag, A., Morsi, M., Belal, M., Galal, S., Abou Arab, A., Abdel-Wahhab, M. (2006). ANTIOXIDANT EFFECTS OF GARLIC AND Panax ginseng AGAINST PCBS-INDUCED OXIDATIVE STRESS IN RATS. Journal of Plant Protection and Pathology, 31(6), 3973-3991. doi: 10.21608/jppp.2006.235233
A. A. EI-Kady,; A. H. Farrag; M. K. S. Morsi; M. H. Belal; S. M. Galal; A. A. Abou Arab; M. A. Abdel-Wahhab. "ANTIOXIDANT EFFECTS OF GARLIC AND Panax ginseng AGAINST PCBS-INDUCED OXIDATIVE STRESS IN RATS". Journal of Plant Protection and Pathology, 31, 6, 2006, 3973-3991. doi: 10.21608/jppp.2006.235233
EI-Kady,, A., Farrag, A., Morsi, M., Belal, M., Galal, S., Abou Arab, A., Abdel-Wahhab, M. (2006). 'ANTIOXIDANT EFFECTS OF GARLIC AND Panax ginseng AGAINST PCBS-INDUCED OXIDATIVE STRESS IN RATS', Journal of Plant Protection and Pathology, 31(6), pp. 3973-3991. doi: 10.21608/jppp.2006.235233
EI-Kady,, A., Farrag, A., Morsi, M., Belal, M., Galal, S., Abou Arab, A., Abdel-Wahhab, M. ANTIOXIDANT EFFECTS OF GARLIC AND Panax ginseng AGAINST PCBS-INDUCED OXIDATIVE STRESS IN RATS. Journal of Plant Protection and Pathology, 2006; 31(6): 3973-3991. doi: 10.21608/jppp.2006.235233
ANTIOXIDANT EFFECTS OF GARLIC AND Panax ginseng AGAINST PCBS-INDUCED OXIDATIVE STRESS IN RATS
The aim of the current study was to evaluate the protective role of garlic and Panax ginseng extract against polychlorinated biphenyls (PCBs)- induced oxidative stress in rats. Eighty female Sprague- Dawley rats were randomly divided into eight groups including the control group, the rat group given garlic alone (5 mg/kg b.w), the rat group administrated Panax ginseng extract alone (20 mg/kg b.w), the rat group given garlic plus Panax ginseng extract and the other 4 groups administrated PCBs (250 1J9/kg b.w) alone or with either garlic, Panax ginseng extract, or with garlic and Panax ginseng extract. The results indicated that rats administrated PCBs caused a significant increase in the activities of AL T, AST, ALP and the levels of uric acid, creatinine, triglycerides and lipid peroxidation whereas it decreased significantly SOD and GPX. Histological examinations of the liver and kidney tissues showed severe histopathological and histochemical changes. Animals treated with garlic, Panax ginseng, garlic and Pan ax ginseng led to a significant elimination of the harmful effects of PCBs in all the biochemical, antioxidant parameters and the histological picture of the liver and kidney. Moreover, the treatment of garlic was found to be more effective than ginseng meanwhile, the combined treatment of garlic and Panax ginseng extract showed a synergistic protective effect than the individual treatment. It could be concluded that both garlic and Panax ginseng extract have a protective role against the PCBs-induced toxicity and these agents may be used pharmaceutically in areas with highly PCBs contamination.
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