COMPARATIVE HISTOPATHOGENIC AND TOXICOLOGICAL EVALUATION OF IN VIVO EXPOSURE TO CHLORPYRIFOS AND ALDICARB IN MALE WISTAR RATS

The toxicological endpoints after chlorpyrifos and atdicarb exposure
        coupled                                  with histological and ultrastructural examinations of multiorgan
        damage                       were assessed in the current study. The tested pesticides were applied
orally in acute and subchronic manner to male Wistar rats at concentrations represent
1/3 and 1/10 LD;c; respectively. Animals under subchroruc intoxication were treeteo
dally for 28 day. Signs of toxicity morbidity and mortality patterns were observed In a
dose-dependent manner. Hepatic-injury marked by significant elevation in serum
indicator enzymes (p < O.001) after acute and subchrcnic exposures was shown in a
type, dose and time-dependent manner. The effect exerted by aldicarb was more
pronounced than cnlorpvrttos either after acute or subchronic exposure. Kidneys
showed signs of renal damage and nephropathy after exposure to both pesticides and
a Significant association (p < O.01) was observed between the length of exposure and
level of damage. However, liver appears to be more sensitive to the effect of the
tested pesticides where histological signs of liver hypertrophy were apparent and
lesions were correlated with biochemical endpoints. The study provides evidence of
both functional and ultrastructural damage elicited by acute and subchronic exposure
to aldicarb and chlorpyrifos.