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EI-Deeb, H., Gabr, W., Khidr, F., EI-Essely, E. (2003). THE HISTOPATHOLOGICAL EFFECTS OF WARFARIN AND CHLOROPHACINONE ANTICOAGULANT RODENTICIDES ON MALE ALBINO RATS. Journal of Plant Protection and Pathology, 28(7), 5685-5698. doi: 10.21608/jppp.2003.251421
H. I. EI-Deeb; W. M. Gabr; Fatma K. Khidr; E. A. EI-Essely. "THE HISTOPATHOLOGICAL EFFECTS OF WARFARIN AND CHLOROPHACINONE ANTICOAGULANT RODENTICIDES ON MALE ALBINO RATS". Journal of Plant Protection and Pathology, 28, 7, 2003, 5685-5698. doi: 10.21608/jppp.2003.251421
EI-Deeb, H., Gabr, W., Khidr, F., EI-Essely, E. (2003). 'THE HISTOPATHOLOGICAL EFFECTS OF WARFARIN AND CHLOROPHACINONE ANTICOAGULANT RODENTICIDES ON MALE ALBINO RATS', Journal of Plant Protection and Pathology, 28(7), pp. 5685-5698. doi: 10.21608/jppp.2003.251421
EI-Deeb, H., Gabr, W., Khidr, F., EI-Essely, E. THE HISTOPATHOLOGICAL EFFECTS OF WARFARIN AND CHLOROPHACINONE ANTICOAGULANT RODENTICIDES ON MALE ALBINO RATS. Journal of Plant Protection and Pathology, 2003; 28(7): 5685-5698. doi: 10.21608/jppp.2003.251421

THE HISTOPATHOLOGICAL EFFECTS OF WARFARIN AND CHLOROPHACINONE ANTICOAGULANT RODENTICIDES ON MALE ALBINO RATS

Article 3, Volume 28, Issue 7, July 2003, Page 5685-5698  XML PDF (1.53 MB)
Document Type: Original Article
DOI: 10.21608/jppp.2003.251421
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Authors
H. I. EI-Deeb; W. M. Gabr; Fatma K. Khidr; E. A. EI-Essely
Plant Protection Research Institute, Agr. Res. Center, Dokki - Giza.
Abstract
The hislopathological effects of warfarin and chlorophacinone anticoagulant
rodenticides were studied on liver. kidney and testis of male albino rats Rattus
nONegicus after administration of sub - lethal doses (1/10and 'I. LD!o) after 15 days
post - treatment. The microscopical examination showed that there were injuries in
these organs depending on the dose level. In liver. both tested compounds induced
dilation of central and portal vein. congestion with lymphocytic infiltration and
necrosis. In kidney , the two tested compounds occurred renal cloudy swelling.
congestion. lymphocytic infiltration, focal areas of haemorrhage in the internal tubular
connective tissues and necrosis. Also, the effect of the two compounds on the testis
showed that there were thickness basement membrane and lymphocytic infiltration of
seminiferous tubules.
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