HISTOPATHOLOGICAL CHANGES IN HEART AND LUNG OF ALBINO RAT TREATED WITH MACHETE HERBICIDE

The present study aims to illustrate the histopathological effect of 1/4 LD50
oral administration of herbicide Machete on heart and lung of albino rats at intervals
1, 2, 3, 4 and 5 weeks post-treatment. Significant decrease in body weight were
recorded, while a significant increase were recorded in heart and lung weight
comparing with control. Also, significant decrease in the number of erythrocytes,
leucocytes, haemoglobin level, haematocrit value and packed cell volume were
observed. Concerning the histopathological changes in heart, there was oedema,
inflammatory cells infiltration in the subendocardial tissue and the myocardial blood
vessels were hyperemic, while changes in lung, there was lymphoid cells aggregation
with hyperemic blood vessels in association with the presence of alveolar
emphysema in diffuse manner. Perivascular lymphoid cells aggregation and
peribronchiolar lymphoid hyperplasia were observed.