TERATOGENIC EFFECTS OF CARBOSULFAN IN FEMALE ALBINO RATS

Document Type : Original Article

Authors

1 Plant Protection Dept., Fac. of Agric., Zagazig Univ.

2 Central Agric. Pesticides lab. (CAPl), Agric. Res. Center, Dokki, Giza.

Abstract

Teratogenic effects of carbosulfan in albino female rats (Rattus rattus)
during organogenesis period (from the 6th to 15th day of gestation) was investigated.
Three doses 18.5,9.25 and 4.63 mglkg b.wt. corresponding to 1/10,1/20,1/40 of the
LD50' respectively, were used. The morphological changes revealed that, the alive
foetus per dam was decreased with selected doses, while the percent post-implantation death, percent of implantation loss and the number of dead foetuses per dam were increased at the tested doses. Also, the mean foetal weights, the mean foetal crown-ramp, length and the mean weight of placenta were reduced markedly.
However, visceral examination of viable foetuses showed dilated renal pelvis,
distended urinary bladder with urine, cleft palate, dilation of lateral ventricles and
       cerebral, hemispheres (a symmetric). The' mostcommon skeletal malformations were
wavy and shorting ribs, reduce o'r absence of sternbrae and absence of digits of fore-
and hind-limbs, and some coccygeal vertebrae. Also, cranial bone absent (skull
incomplete ossificationj-was observed.
Journal of Plant Protection and Pathology
Volume 27, Issue 6
June 2002
Pages 4131-4143

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