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Eweis,, E. (2000). BIOCHEMICAL EFFECTS OF CALCIFEROL RODENTICIDE ON ALBINO MICE. Journal of Plant Protection and Pathology, 25(4), 2351-2356. doi: 10.21608/jppp.2000.258835
E. A. Eweis,. "BIOCHEMICAL EFFECTS OF CALCIFEROL RODENTICIDE ON ALBINO MICE". Journal of Plant Protection and Pathology, 25, 4, 2000, 2351-2356. doi: 10.21608/jppp.2000.258835
Eweis,, E. (2000). 'BIOCHEMICAL EFFECTS OF CALCIFEROL RODENTICIDE ON ALBINO MICE', Journal of Plant Protection and Pathology, 25(4), pp. 2351-2356. doi: 10.21608/jppp.2000.258835
Eweis,, E. BIOCHEMICAL EFFECTS OF CALCIFEROL RODENTICIDE ON ALBINO MICE. Journal of Plant Protection and Pathology, 2000; 25(4): 2351-2356. doi: 10.21608/jppp.2000.258835

BIOCHEMICAL EFFECTS OF CALCIFEROL RODENTICIDE ON ALBINO MICE

Article 1, Volume 25, Issue 4, April 2000, Page 2351-2356  XML PDF (465.86 K)
Document Type: Original Article
DOI: 10.21608/jppp.2000.258835
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Author
E. A. Eweis,
Department of Econ. Entomol. and Pesticides, Faculty of Agriculture, Cairo University, Egypt.
Abstract
Median lethal dose of Claciferol (Vitamin D) against albino mice Mus musculus was estimated.   Calciferol could be classified as a highly toxic compound to albino mice as its LD50 values to the (immature and adult) were 47 and 60 mg/kg, respectively.  Three doses representing 1/10, 1/20 and 1/30 of the LD50 were administered orally for 2 weeks.
In treated animals the rate of body weight gain, water and food consumption were decreased clearly at 1/10 LD50 of  Calciferol than other doses.  Similarly, organs weight/body weight ratio was lower than that observed in non-treated animals.
Calcium, phosphorus and cholesterol levels were affected.  The tissue-specific enzymes alkaline phosphates (AP), the amount of urea, creatinine and total proteins of serum, liver and kidney were significantly increased.
Keywords
Calciferol; calcium; phosphorus; (AP); Cholesterol; urea; creatinine and total proteins
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